Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice.
نویسندگان
چکیده
Persistent infection was established in SCID mice given 10(7) Cryptosporidium parvum oocysts. Nine groups of infected SCID mice were inoculated with 10(6), 10(5), or 10(4) total spleen cells, CD8-depleted spleen cells, or CD4-depleted spleen cells from naive BALB/c donors. Infection was significantly reduced in all treatment groups. The most profound effect occurred with spleen cell preparations containing CD4 T lymphocytes but depleted of CD8 T lymphocytes.
منابع مشابه
THE ROLE OF B-CELLS IN THE DEVELOPMENT OF IMMUNITY TO CRYPTOSPORIDIUM INFECTION
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عنوان ژورنال:
- Infection and immunity
دوره 62 4 شماره
صفحات -
تاریخ انتشار 1994